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Conscious-Like Activity Found In the Dying Brain

Reports of near-death experiences—with tales of white light, visits from departed loved ones, hearing voices, among other attributes—capture our imagination and are deeply engrained in our cultural landscape.

The fact that these reports share so many common elements begs the question of whether there is something fundamentally real underpinning them—and that those who have managed to survive death are providing glimpses of a consciousness that does not completely disappear, even after the heart stops beating.

A study published in the Proceedings of the National Academy of Science, provides early evidence of a surge of activity correlated with consciousness in the dying brain.

The study, led by Jimo Borjigin, Ph.D., associate professor in the Department of Molecular & Integrative Physiology and the Department of Neurology, and her team is a follow up to animal studies conducted almost 10 years ago in collaboration with George Mashour, M.D., Ph.D., the founding director of the Michigan Center for Consciousness Science.

Similar signatures of gamma activation were recorded in the dying brains of both animals and humans upon a loss of oxygen following cardiac arrest.

“How vivid experience can emerge from a dysfunctional brain during the process of dying is a neuroscientific paradox. Dr. Borjigin has led an important study that helps shed light on the underlying neurophysiologic mechanisms,” said Mashour.

The team identified four patients who passed away due to cardiac arrest in the hospital while under EEG monitoring. All four of the patients were comatose and unresponsive. They were ultimately determined to be beyond medical help and, with their families’ permission, removed from life support.

Upon removal of ventilator support, two of the patients showed an increase in heart rate along with a surge of gamma wave activity, considered the fastest brain activity and associated with consciousness.

Furthermore, the activity was detected in the so-called hot zone of neural correlates of consciousness in the brain, the junction between the temporal, parietal and occipital lobes in the back of the brain. This area has been correlated with dreaming, visual hallucinations in epilepsy, and altered states of consciousness in other brain studies.

These two patients had previous reports of seizures, but no seizures during the hour before their deaths, explains Nusha Mihaylova, M.D., Ph.D., a clinical associate professor in the Department of Neurology who has collaborated with Borjigin since 2015 by collecting EEG data from deceased patients under intensive care unit treatment. The other two patients did not display the same increase in heart-rate upon removal from life support, nor did they have increased gamma activity.

Because of the small sample size, the authors caution against making any global statements about the implications of the findings. They also note that it’s impossible to know in this study what the patients experienced because they did not survive.

“We are unable to make correlations of the observed neural signatures of consciousness with a corresponding experience in the same patients in this study. However, the observed findings are definitely exciting and provide a new framework for our understanding of covert consciousness in the dying humans,” she said.

Larger, multi-center studies including EEG-monitored ICU patients who survive cardiac arrest, could provide much needed data to determine whether or not these bursts in gamma activity are evidence of hidden consciousness even near death.

Additional authors on this paper include Gang Xu, Duan Li, Fangyun Tian, Peter M. Farrehi, Jack M. Parent and Michael Wang Paper cited: “Surge of neurophysiological coupling and connectivity of gamma oscillations in the dying human brain,” Proceedings of the National Academy of Science. https://www.pnas.org/doi/10.1073/pnas.2216268120

AR #106

Near Death Experience Before Moody

by Michael Tymn

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Does Newly Discovered Intracellular Electricity Power Biology?

The human body relies heavily on electrical charges. Lightning-like pulses of energy fly through the brain and nerves and most biological processes depend on electrical ions traveling across the membranes of each cell in our body.

These electrical signals are possible, in part, because of an imbalance in electrical charges that exists on either side of a cellular membrane. Until recently, researchers believed the membrane was an essential component to creating this imbalance. But that thought was turned on its head when researchers at Stanford University discovered that similar imbalanced electrical charges can exist between microdroplets of water and air.

Now, researchers at Duke University have discovered that these types of electric fields also exist within and around another type of cellular structure called biological condensates. Like oil droplets floating in water, these structures exist because of differences in density. They form compartments inside the cell without needing the physical boundary of a membrane.

Inspired by previous research demonstrating that microdroplets of water interacting with air or solid surfaces create tiny electrical imbalances, the researchers decided to see if the same was true for small biological condensates. They also wanted to see if these imbalances sparked reactive oxygen,  “redox,” reactions like these other systems.
“In a prebiotic environment without enzymes to catalyze reactions, where would the energy come from? This discovery provides a plausible explanation of where the reaction energy could have come from, just as the potential energy that is imparted on a point charge placed in an electric field.” (https://www.sciencedirect.com/science/article/abs/pii/S2451929423001535)

Because the Chilkoti laboratory specializes in creating synthetic versions of naturally occurring biological condensates, the researchers were easily able to create a test bed for their theory. After combining the right formula of building blocks to create minuscule condensates, with help from postdoctoral scholar Marco Messina in? Christopher J. Chang’s group at the University of California – Berkeley, they added a dye to the system that glows in the presence of reactive oxygen species.

Their hunch was right. When the environmental conditions were right, a solid glow started from the edges of the condensates, confirming that a previously unknown phenomenon was at work. Dai next talked with Richard Zare, the Marguerite Blake Wilbur Professor of Chemistry at Stanford, whose group established the electric behavior of water droplets. Zare was excited to hear about the new behavior in biological systems, and started to work with the group on the underlying mechanism.

AR #38

Rupert Sheldrake’s Seven Senses

by Cynthia Logan